So vanilla poke red setups will still work but it will just be harder to achieve things? For example, thunderbolt is one of the strongest electric attacks but is no longer acquired after the victory against surge, but I assume you can acquire it further into the game?
The only kanto walkthrough I found on this site mentions thunderbolt as a reward, so it's out of date and can't be followed properly. It also mentions TMs in the world that are not actually there.